Trump threatens tariffs will be reinstated if Mexico fails to pass immigration

first_img What you need to know about passing the family cottage to the next generation U.S. President Donald Trump said on Friday Mexico’s government had reached a deal with the United States to avert a tariff war by pledging to take “strong measures” to contain the migration of mostly Central Americans crossing the southern U.S. border.Oliver Contreras/Pool via Bloomberg advertisement WASHINGTON — President Donald Trump said on Monday the United States had signed another portion of an immigration and security deal with Mexico that would need to be ratified by Mexican lawmakers.He did not provide details but threatened tariffs if Mexico’s Congress did not approve the plan.“We have fully signed and documented another very important part of the Immigration and Security deal with Mexico, one that the U.S. has been asking about getting for many years. It will be revealed in the not too distant future and will need a vote by Mexico’s legislative body,” Trump tweeted.“We do not anticipate a problem with the vote but, if for any reason the approval is not forthcoming, tariffs will be reinstated.” ….We do not anticipate a problem with the vote but, if for any reason the approval is not forthcoming, Tariffs will be reinstated!— Donald J. Trump (@realDonaldTrump) June 10, 2019Trump said on Friday Mexico’s government had reached a deal with the United States to avert a tariff war by pledging to take “strong measures” to contain the migration of mostly Central Americans crossing the southern U.S. border.Related Stories:UPDATE 2-Mexican president thanks Trump for tariff comments as peso strengthensPompeo to meet with Mexico’s foreign minister to discuss immigration, tradeMexican peso will dance in July to rhythm of USMCA and TrumpTrump had threatened to impose 5% import tariffs on all Mexican goods from Monday if Mexico did not agree to his demands to tighten its borders. His announcement of a deal came after three days of Mexico-U.S. negotiations in Washington.“The Tariffs scheduled to be implemented by the U.S. on Monday, against Mexico, are hereby indefinitely suspended,” Trump said on Twitter on Friday evening.“Mexico, in turn, has agreed to take strong measures to stem the tide of Migration through Mexico, and to our Southern Border. This is being done to greatly reduce, or eliminate, Illegal Immigration coming from Mexico and into the United States,” Trump added.U.S. equity futures climbed on Monday together with stocks in Europe and Asia after Trump suspended plans for punitive tariffs on Mexican imports. Sovereign bonds fell across the board, along with gold and the yen, as demand for havens ebbed. Email Trump threatens tariffs will be reinstated if Mexico fails to pass immigration deal Stocks up on possibility of deal Twitter 3 Comments June 10, 20197:29 AM EDT Filed under News Economy Featured Stories Morecenter_img Sponsored By: ← Previous Next → Facebook Join the conversation → Share this storyTrump threatens tariffs will be reinstated if Mexico fails to pass immigration deal Tumblr Pinterest Google+ LinkedIn Recommended For YouMDA Awarded Canadian Government Contract to Deliver Search and Rescue Repeaters for SatellitesSingapore-based company is buying the biggest shipping container terminal in eastern CanadaInagene Diagnostics Inc. Announces New CEOPRECIOUS-Gold drops as bets fade for big Fed rate cut fade; eyes on trade talks’John Wick 3′ dethrones ‘Avengers: Endgame’ with $57 million Reuters Comment Redditlast_img read more

Panamera PHEV TechArt Grand GT Might Be The Ultimate Wagon

first_img Top-Line Porsche Taycan To Be Called “Taycan Turbo” Source: Electric Vehicle News Porsche Tells Us How To Correctly Pronounce Taycan And it can run on full electric mode, too.When Porsche launched the Panamera Turbo S E-Hybrid Sport Turismo in 2017, I immediately thought that it’s the ultimate wagon. Armed with great looks and even greater performance figures, it immediately outshined the Mercedes-AMG E 63 S Wagon and the Audi RS 6 Avant Performance, especially with the Panamera’s 671-horsepower electronically-assisted power.More Porsche News But DJ La Fuente, a Dutch disc jockey who has quite a taste in cars, thinks otherwise. He wanted more. He thought that the Panamera Sport Turismo wasn’t exclusive enough. So he contacted Porsche tuning experts, TechArt to make him his Grand GT.With just a glance, you’ll immediately notice that La Fuente’s Grand GT isn’t any ordinary Porsche. The blacked-out color theme and widened body is a dead giveaway, but wait until you see the interiors. The low-resolution images above don’t do justice to the car; you have to watch the video above by Shmee.La Fuente is a man who loves to drive his cars. When Shmee asked when did he receive his Grand GT, he said that he ordered the car by April 2018 but since he had it done by TechArt first, he only got his Grand GT two to three months ago. Surprisingly, with only a few months to his possession, his car has already done 20,000 kilometers (12,427 miles).The car-loving DJ said that his Grand GT is currently rated at 680 horsepower, but TechArt is updating it to 770 soon through the German tuner’s power upgrade. Although, we don’t think La Fuente is going to stop there.Even better, with all the body kits and custom exhausts installed on La Fuente’s Grand GT, it can still run on full electric mode. That’s pretty nifty. Porsche Turns To MAN For Electric Heavy-Duty Delivery Trucks Author Liberty Access TechnologiesPosted on January 2, 2019Categories Electric Vehicle Newslast_img read more

Video Tesla Model 3 Tip Of Week This Nifty Feature Is Overlooked

first_imgThe Model 3 features “Hill Hold.” If you’re a long-time Tesla owner — and especially one that lives in a hilly area — you’re probably well aware of this feature. However, many owners are not. Essentially, if the car is stopped, you can push a button on the touch screen to keep it in place, rather than having to continue depressing the brake pedal. Once you’re ready to proceed, you can either tap the brake (which will send your car in whatever direction gravity decides), or push the accelerator pedal to disengage the feature.We drive in Smoky Mountain National Park on a regular basis. This feature would be ideal in such an area. But, honestly, it may be just as convenient when you’re sitting in a driveway waiting to pick someone up or prepping to head out.Did you know about Tesla’s Hill Hold feature? If so, in what other situations may hill hold come in handy? In addition, let us know if the feature works well and/or if there are any issues we should be made aware of.Video Description via Now You Know on YouTube:Model 3 Hill Hold Feature | Tip of the WeekThis week’s Model 3 Tip is on the Hill Hold feature! Tesla Model 3 Cold Weather Driving Tips & Tricks For some, this Tesla Model 3 feature could come in really handy.After a few reviews surface about a new car, many subsequent reviews are much the same. This is because journalists read the previous reviews for insight. Due to this situation, many an article references the same set of features. Tesla vehicles come loaded with interesting features not found in many competing models. It seems owners are still discovering new details and quirks. This may also be due to the fact that virtually all Tesla Model 3 features are controlled via the car’s touch screen. It turns out the Tesla Model 3 has a helpful feature that has seemingly gone unnoticed by many.More Tesla Model 3 Features And Tips: Tesla Model 3 Features Explored And Demonstrated Tesla Model 3: Top Time-Saving Tips And Some Tricks: Video Source: Electric Vehicle News Author Liberty Access TechnologiesPosted on February 7, 2019Categories Electric Vehicle Newslast_img read more

Davydenko in the clear over match fixing allegations

first_imgShare on Twitter Share on Pinterest Tennis Share on Twitter Stephen Wilson, Associated Press Share on Facebook Since you’re here… … we have a small favour to ask. The Guardian will engage with the most critical issues of our time – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.More people are reading and supporting The Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we have chosen an approach that allows us to keep our journalism accessible to all, regardless of where they live or what they can afford. But we need your ongoing support to keep working as we do.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We need your support to keep delivering quality journalism, to maintain our openness and to protect our precious independence. Every reader contribution, big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. Nikolay Davydenko was cleared by the ATP yesterday after a year-long investigation into suspicious betting patterns on a match the Russian lost to a lowly-ranked opponent. The ATP, the governing body of men’s tennis, said it found “no evidence” of wrongdoing by Davydenko, Argentinian Martin Vassallo Arguello or anyone else associated with their match in Sopot, Poland, on August 2 last year.”The ATP has now exhausted all avenues of inquiry open to it and the investigation is now concluded,” the association said. Davydenko, then ranked No5 in the world, pulled out of the match against the 87th-ranked Vassallo Arguello in the third set, citing a foot injury. Share via Email The ATP has cleared Nikolay Davydenko after a year-long investigation into his loss to Martin Vassallo Arguello. Photograph: Jacques Demarthon/AFP/Getty Images Share on LinkedIn Support The Guardian Fri 12 Sep 2008 19.01 EDT The Recap: sign up for the best of the Guardian’s sport coverage Share on Facebookcenter_img news This article is more than 10 years old First published on Fri 12 Sep 2008 19.01 EDT Share on Messenger This article is more than 10 years old Topics Tennis Shares00 Share via Email Betfair, an online bookmaker, voided all bets on the match. It received about £3.4m ($7m) in wagers on the match, 10 times the usual amount for a similar-level match. Most of the money was put on Arguello, even after he lost the first set. ATP investigators spoke to Davydenko, his wife and family members and reviewed telephone records. This summer, Davydenko said he may have inadvertently tipped off bettors by talking too loudly about his injury to his wife during the tournament. Davydenko, now ranked No6, and Arguello have always firmly denied any wrongdoing.In the statement, the ATP said it interviewed “a number of individuals involved in the match” and reviewed betting account details of those who placed bets. It also reviewed phone records from Davydenko, Vassallo Arguello and members of their support personnel. However, “certain individuals” declined to provide phone records. After lengthy legal proceedings, some records were eventually turned over but they had been “destroyed” by telephone companies in line with data protection laws, the ATP said.Speaking at Wimbledon this year, Davydenko said Russian spectators might have overheard him talking to his wife and entourage in the stands at the Sopot tournament. “Everything was going on. I spoke in the centre court with my wife … [in] Russian,” he said. “Maybe it’s possible, if I can say something, ‘I don’t want to play or I can retire,’ … some people can understand.”Leading betting agencies last year presented world tennis authorities with a dossier of matches involving irregular gambling patterns over the last five years. Of those, 45 are under investigation, including eight at Wimbledon.The ATP has approved a list of 15 recommendations from an independent review panel to combat potential for corruption in the sport. Under new guidelines, players are required to report any suspicious contact from gambling syndicates within 48 hours. Potential sanctions include life bans for players who are found guilty of match fixing. Read more Davydenko in the clear over match fixing allegations Share on WhatsApp Reuse this contentlast_img read more

Much Ado About…Little

first_img Learn More & Register I didn’t come up with the headline, but I did participate in an extensive Q&A about Walmart’s FCPA scrutiny with Metropolitan Corporate Counsel. The Q&A was published in its most recent issue with the headline: “Much Ado About…Little? How a ‘garden variety’ FCPA investigation of Walmart grabbed the spotlight.”The Q&A is republished below with permission.Q: When I read The New York Times front-page article in 2012 about Walmart’s alleged bribes in Mexico, I thought it was going to be the U.S. equivalent of Siemens in Germany. Before I ask you about that, can you bring us up to date on Walmart’s FCPA investigation? What has happened over the past five years?The first point is that Walmart’s FCPA scrutiny most certainly did not begin with the April 2012 New York Times article. That is one of the biggest myths in the FCPA space. It is a matter of public record, and beyond dispute, that Walmart disclosed its FCPA scrutiny in November 2011. It’s now almost six years old. There have been other FCPA enforcement actions that have similarly lasted longer than five years, and Walmart’s scrutiny has really followed a fairly typical path. All instances of FCPA scrutiny have what I’ll call a point of entry. Walmart’s point of entry was conduct in Mexico. Most FCPA enforcement actions then typically expand beyond that point of entry, and the company becomes subject to FCPA scrutiny and does internal investigations in several other countries. And that’s what happened here. Anyone knowledgeable about FCPA enforcement would have recognized the April 2012 New York Times article as highly selective, as leaving out various relevant pieces of information, not talking about the law in a comprehensive and complete way. Just because a talented journalist at a leading newspaper devotes an article to an instance of FCPA scrutiny does not make that scrutiny more notable from a legal perspective.Q: Is any resolution in sight?There has been public reporting that there is perhaps an agreement in principle to resolve Walmart’s FCPA scrutiny in the aggregate amount of $300 million. Now, I don’t believe everything I read in the media. When it comes to the FCPA there are numerous instances of the media getting it completely wrong. But taking that report at face value, some people have expressed shock and outrage at that number because early on a $1 billion settlement figure was bantered about by some commentators. That was uninformed commentators speculating and was not based on facts. I predicted very early that Walmart was not likely to be a top five FCPA enforcement action of all time. The reason is the nature of Walmart’s scrutiny. All of the cases in the top 10 involve what I call a foreign-government-procurement type of FCPA enforcement. That’s not the nature of Walmart’s FCPA scrutiny. Walmart is facing FCPA scrutiny because of license, permit, certification-type issues. Let’s just call that, for lack of a better word, non-foreign-government procurement. There’s never been a license permit-type case in the FCPA’s top 10.Q: Did you ever think it was going to rival Siemens in its impact?This was never in the Siemens-type category. Siemens was a situation where, in the words of the U.S. Department of Justice and the Securities and Exchange Commission, it had “a culture of bribery” at the highest levels of the company. Even The New York Times article stated that executives at Walmart’s Mexican subsidiary were concealing conduct from corporate leaders in Bentonville, Arkansas. There was no allegation or suggestion whatsoever that executives in Bentonville were active, knowing participants. What made this story take on a life of its own is not the nature of the scrutiny, it’s the nature of the company. Walmart is a divisive company that people love to love and people love to hate. From a legal perspective, and I said this from day one, this is a garden-variety type of FCPA story.Q: One of the things that made it a powerful story for me, as a journalist who covers the legal beat, is that you had a lawyer in Mexico who was making payments and was talking about them on the record. There was an incredible wealth of detail in this story that brought us inside an FCPA case as it was breaking in the public realm.There are always going to be emails and documents and real people involved in any instance of FCPA scrutiny. That doesn’t make Walmart’s FCPA scrutiny unique. Again, it’s just that The New York Times chose to focus on Walmart’s FCPA scrutiny among the many dozens, if not hundreds, of other instances that they could’ve focused on. You can look at these emails and documents in isolation. This is not a complete and accurate picture, a holistic view of what was happening here. Just because The New York Times reports something or posts a document on its website in isolation, that doesn’t mean much of anything. If the allegations or the findings or suggestions or inferences in The New York Times article are true, one would expect to see those followed through in the DOJ and SEC enforcement action against Walmart. That hasn’t yet occurred.Even The Wall Street Journal has reported that much of what was in The New York Times article has not proven to be true or the magnitude of it was severely, significantly overblown. That’s how you sell newspapers. That’s how you win Pulitzer Prizes. I was on a panel several years ago with David Barstow [the Times reporter who shared a Pulitzer Prize for his Walmart reporting], and I was pointing out some of the holes in the article, from an FCPA perspective. His general response was, “I tell stories. I leave the law to other people.” Well, when you’re writing an article about a company and a company’s conduct under a specific law, excuse me, you have to get the law right.Can you give me an example?The FCPA contains an express facilitation payment exception. Congress specifically drafted the FCPA in a way such that payments in connection with routine governmental actions are not actionable. We can debate the wisdom of that, and that’s a valid discussion to have, but it’s in the law. Moreover, even accepting at complete face value everything in The New York Times article, we have conduct stretching back to 2005, 2006. It’s a matter of black-letter law that there are statutes of limitations. Indeed, the U.S. Supreme Court just last week reiterated the fact that in actions, including those under the Foreign Corrupt Practices Act, there’s such a thing as a statute of limitations, which impacts settlement amounts. Again, I completely agree with you and everyone else that The New York Times article elevated Walmart’s scrutiny to a very high level – created a media feeding frenzy. But that doesn’t, in and of itself, make it “a big case.”Has the Walmart FCPA investigation resulted in any big changes to date?Big changes in what?It does seem to have resulted in Walmart’s instituting reforms on a very large scale.Yeah, I think it would be undisputed that Walmart’s FCPA scrutiny has resulted in the company implementing some additional policies and procedures. And that has resulted in the company becoming an undisputed best practices leader in this space, regardless of whatever may or may not have happened seven to 10 years ago. Again, one can say the same exact thing regarding most companies that experience FCPA scrutiny. Most are going to learn some things, are going to devote additional resources to FCPA compliance, are going to revise policies and procedures and processes. Again, there’s nothing unique about what Walmart has been doing. What is unique is Walmart’s disclosure of what it’s been doing. From my perspective, Walmart has been very forthright and transparent in its global ethics and compliance report that it’s publicly released over the last four or five years. That’s not to suggest Walmart’s the only company doing those sorts of things. But not all companies necessarily disclose what they’re doing to the extent Walmart has.What lessons would you like companies to draw from all this?Don’t fall hook, line and sinker just because a journalist writes something about the FCPA. Don’t base policy positions, don’t stake your reputation as some FCPA commentators have done, solely based on an article in a newspaper. Let the facts come out. The facts still haven’t come out yet. We don’t even have an enforcement action, but from day one people were staking positions, making policy arguments based solely on a newspaper article. That’s irresponsible commentary. All companies active in the FCPA space, and adhering to best practices, already knew that doing business in China and Mexico and India presented an FCPA risk. Companies doing business in the global marketplace, adhering to best practices, already knew that interactions with licensing and regulatory officials presented an FCPA risk.That, of course, is the other side of this kind of enforcement: the potential reputational risk that companies face just because they’re under scrutiny.I usually respond to that issue by taking a step back and asking, “How does one even measure reputational harm, or how does one even measure a company’s reputation?” On one level, if a company’s reputation is bad, and has sunk because of an instance of FCPA scrutiny, you would think it would be reflected in a company’s stock price. Because there was so much misinformation in the public domain regarding The New York Times story, Walmart’s stock price did fall very significantly within 48 to 72 hours. Once people started to take a deep breath and realize what was really going on, the company’s stock price completely rebounded.If history is any guide, when the Walmart FCPA enforcement action is announced, whenever that is, the company’s stock price is likely to go up because now it’s over. You’ve mentioned Siemens. Did Siemens suffer any reputational damage because of its blockbuster FCPA enforcement action? Well that begs a question of how one even measures reputational damage. What we know is that a few days after that blockbuster enforcement action in 2008, the U.S. government deemed Siemens a responsible government contractor for purposes of federal government contracting. It didn’t impact Siemens contracts or business with the U.S. government in any material way.It’s a long-winded way of saying a lot of people like to talk about reputational damage, but what does it really mean? Does it mean a company’s stock price? Does it mean how a company is perceived? How do you even measure how a company is perceived? I could go to my local Walmart today, and I guarantee you 99.9 percent of people in that store probably aren’t even aware that Walmart is under FCPA scrutiny or may not have even heard about the Foreign Corrupt Practices Act.I want to turn now to another subject that some have predicted could have a profound effect on FCPA jurisprudence: the U.S. Supreme Court’s Kokesh decision. What’s your view?It will not have a profound impact on FCPA enforcement because most companies under FCPA scrutiny simply roll over and play dead. Even though the Supreme Court unanimously concluded that disgorgement is subject to a five-year statute of limitations period, what difference does that make when a company under FCPA scrutiny, to demonstrate its cooperation, agrees to waive statute of limitation defenses? Last Friday there was an FCPA enforcement action brought by the Department of Justice against The Linde Group, seeking disgorgement. And the conduct at issue took place in 2006 – in other words, 11 years prior to the enforcement action. So, in the one FCPA enforcement action brought since Kokesh, it had zero relevance. It sounds like a basic point, but it’s such an extremely important point: The law only matters to the extent that a defendant, whether a corporate defendant or an individual, is willing to mount a legal defense based upon the law and the facts. There are a lot of things that should impact FCPA enforcement, but they don’t because the law often doesn’t matter. It’s a game of risk aversion. It’s a game of cooperation. It’s a game of how do we make this adversary who carries a sharp and big stick go away as quickly and efficiently as possible? FCPA Institute – Boston (Oct. 3-4) A unique two-day learning experience ideal for a diverse group of professionals seeking to elevate their FCPA knowledge and practical skills through active learning. Learn more, spend less. CLE credit is available.last_img read more

Friday Roundup

first_imgThis Financial Times article criticizes U.K. prosecutors for dropping inquiries into individuals associated with Rolls Royce. However, charging an individual with a crime is an awesome power the government possesses. It changes the lives of real people, their real family, and their real reputation. Prosecutors should be applauded (not criticized) when exercising restraint and not bringing charges because there is insufficient evidence for a realistic prospect of conviction.Just saying.This FCPA Blog post  seems to suggest that there is value in having short simple compliance codes such as “dress appropriately” or “don’t pay bribes.”However, in the PTC enforcement action, among the internal control dings the company received from the SEC was the following:“PTC’s Code of Ethics and Anti-Bribery policies for the provision of business entertainment were vague (i.e., stating that employees should use “good taste” and consider the “customary business standards in the community” when providing business entertainment) and not risk-based to China.”Just saying.Reading and Listening StackThe most recent edition of the always informative FCPA Update from Debevoise & Plimpton is here Learn More & Registerlast_img read more

Raising Awareness of Childhood Dementia

first_imgPaul completed a PhD at Birmingham University, where he studied the genetics of rare paediatric metabolic disorders and became interested in molecular and cellular basis of intracellular trafficking disorders.Paul moved his lab to UCL MRC Laboratory for Molecular and Cell Biology in 2011 and has continued to carry out research at the Great Ormond Street Hospital for Children. His current research focuses on development of novel therapies for children with inherited metabolic disorders. What are the aims of the ‘Dementia Strikes Children Too’ campaign?The Dementia Strikes Children Too campaign was set up to raise awareness of childhood dementia among physicians and parents. We wanted to make it known that these conditions, although rare individually, are not so rare when they’re taken as a group and that they must be diagnosed.At the moment, children can wait up to 10 years for a diagnosis. Being able to reduce this delay was incredibly important to us. These are devastating  conditions. Imagine that your child has been developing normally and then suddenly they begin to lose all their skills and die early, sometimes in pain. If we can prevent that as well by developing novel treatments, that’s a big deal.Even without the new treatments coming in, the support that can be provided now is quite important. Both psychologically as well as medically.Where can readers find out more information? How is childhood dementia diagnosed, what is the typical age of onset?As I said, there are various conditions that can cause childhood dementia. In a specific example, patients with CLN2 disease (a type of Batten Disease) typically show a normal developmental profile until they are about the age of three. After that, they suddenly begin to lose their speech, and start having epileptic seizures. They become clumsy, and then slowly start losing their vision.Often, the first seizure occurs around the age of three, and by four and a half years old, most children with this condition are unable to walk. By the age of about six, their vision will be significantly impaired and sadly, most children will die by the age of 10 years old.As childhood dementia encompasses a group of conditions, it is difficult to diagnose using one test. Some of the conditions can be diagnosed quite simply by sending a blood test to the laboratory, and testing for a specific enzyme function. For example, CLN2 type Batten Disease is caused by a lack of an enzyme called TPP1, function of which can be assayed in the blood of the patient.The problem with diagnosing childhood dementia early is that the initial symptoms are non-specific, so they’re often not considered important. These diseases are rare and most of the general practitioners and even general pediatricians, don’t see these conditions very frequently. They will have seen maybe one case in their working life, sometimes none, and if they don’t think about these conditions, they may not order specific tests to diagnose them.Why is it important to raise awareness of childhood dementia?It’s important to raise awareness of childhood dementia in the medical community so that physicians start to recognize that a child who is presenting with clumsiness after developing completely normally for the first few years of life, or whose speech is deteriorating, may have one of the forms of childhood dementia. Children may be labelled as “lazy”, instead of being investigated for the condition.Just knowing the diagnosis makes a huge difference, because then the parents don’t have to go for continuous testing and assessments. In addition, being able to say to the school and everyone else that their child has a specific condition that will require counseling and extra help, is extremely important.There are also therapies that are being developed, and some that are already available, that can help with the symptoms or even prevent deterioration. Having the diagnosis enables children to be enrolled onto clinical research trials and have access to these novel therapies. Interview conducted by Kate Anderton, B.Sc. (Editor)May 18 2018 Thought LeadersProfessor Paul GissenHonorary Consultant in Paediatric Metabolic DiseasesGreat Ormond Street HospitalAn interview with Professor Paul Gissen, conducted by Kate Anderton, BScWhat is childhood dementia, how common is it?Childhood dementia is a group of conditions which can occur at any time during childhood.Credit: Evgeny Atamanenk/Shutterstock.comFortunately, it is not very common. If you take each individual disorder, the frequency could be between one in twenty thousand people in the population, to one in a million in the population. But if you take the whole group, then the prevalence will probably be one in 10 thousand or even more frequent than that.What causes childhood dementia? Are the symptoms similar to adult dementia?Many gene defects have been linked to childhood dementia. Often, these genetic abnormalities are the same ones that cause dementia in adults, but the more severe forms are linked to childhood dementia. The mutations can either be sporadic, autosomal dominant or autosomal recessive, meaning the child can either inherit the mutation from one or both parents, or neither.Childhood dementia is mostly caused by single gene defects. One example is CLN2 type Batten disease which is a disorder caused by a mutation in the gene that affects the function of lysosomes. These are cellular organelles that are involved in the recycling of proteins, fats and other materials.Defects in lysosomal function can lead to an accumulation of molecules in the cell, ultimately resulting in cell death. Childhood dementia can also be caused by primary defects affecting other organelles in the cell, such as, for example, peroxisomes.In most cases, the symptoms are identical to dementia in adults. Patients may develop completely normally from birth, and show no signs of the disease for the first few years of life. However, at some point, they start losing the skills required for development.To start with, children may appear more clumsy than usual and certain movements become more difficult. Over time, they lose their ability to walk independently and become completely reliant on their parents for support.Slowly, the child begins to lose their ability to communicate, and their speech becomes more and more difficult to understand. They struggle to learn new words compared to their peers, and slowly stop being able to form sentences. After that, only occasional words or occasional syllables that can be heard.Children with dementia also lose the ability to retain information. They struggle to remember things in the near past and of course, when you lose the ability to remember things, learning becomes extremely difficult.In some types of childhood dementia, such as CLN2, children can also lose their vision. This is a gradual process that, after many years, causes them to go blind. In other forms of dementia, such as Niemann Pick type C disease, children may lose their ability to hear.center_img Dementia Strikes Children Too Professor Gissen’s Profile for UCL About Professor Paul GissenPaul Gissen is the Head of “Genetics and Genomic Medicine” academic programme at the UCL GOS Institute of Child Health and Honorary Consultant in Paediatric Metabolic Diseases at Great Ormond Street Hospital.In 1995, Paul graduated with a medical degree with commendation from the University of Glasgow. He went on to complete paediatrics training at Manchester, Sheffield and Birmingham Children’s hospitals with specialization in Inherited Metabolic Disorders.last_img read more

Translate Bio collaborates with Sanofi to develop mRNA vaccines for infectious diseases

first_img Source: Jun 11 2018Translate Bio, a clinical-stage messenger RNA (mRNA) therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction, announced today a multi-year research and development collaboration and exclusive licensing agreement with Sanofi Pasteur, the vaccines global business unit of Sanofi, to develop mRNA vaccines for up to five undisclosed infectious disease pathogens.Under the agreement, Translate Bio and Sanofi Pasteur will jointly conduct research and development activities to advance mRNA vaccines during an initial three-year research term. Sanofi Pasteur will make an upfront payment of $45 million to Translate Bio. In total, Translate Bio is eligible to receive up to $805 million in payments, which also includes certain development, regulatory and sales-related milestones across several vaccine targets, and option exercise fees if Sanofi Pasteur exercises its option related to development of vaccines for additional pathogens. In addition, Translate Bio is also eligible to receive tiered royalty payments associated with worldwide sales of the developed vaccines. Sanofi Pasteur will pay for all costs during the research term and will receive exclusive worldwide commercialization rights. Translate Bio will be responsible for clinical manufacture and will be entitled to additional payments under a separate supply agreement to be established.Related StoriesNew protein target for deadly ovarian cancerNew gene-editing protocol allows perfect mutation-effect matchingSchwann cells capable of generating protective myelin over nerves finds research”Sanofi Pasteur is pursuing a variety of emerging technologies that will allow us to continue to lead in research and development of next-generation vaccines,” said John Shiver, Senior Vice President, R&D, Sanofi Pasteur. “We believe mRNA technology has significant potential for rapid and versatile manufacturing, reduced industrialization costs for multiple vaccines, and the improved breadth of immune response for infectious disease vaccines. The Translate Bio platform may allow us to further address medical needs worldwide, including those not readily accessible using conventional vaccine strategies.””Sanofi Pasteur is at the forefront of vaccine research and development which makes them an ideal partner as we expand upon our promising early efforts in vaccines,” said Ronald Renaud, Chief Executive Officer, Translate Bio. “We believe that this partnership validates the potential of our mRNA platform, and also enables us to apply our mRNA technology beyond the current therapeutic applications that we are pursuing in cystic fibrosis (CF) and ornithine transcarbamylase (OTC) deficiency, ultimately advancing our goal of delivering innovative medicines to patients.”The transaction is subject to customary closing conditions, including the expiration of the applicable waiting period under the Hart Scott Rodino Antitrust Improvements Act of 1976 in the United States.last_img read more

OHSU professor conducts clinical trial with artificial pancreas using Xeris liquid glucagon

first_img Source: Aug 17 2018Xeris Pharmaceuticals, Inc., a specialty pharmaceutical company leveraging its novel technology platforms to develop and commercialize ready-to-use injectable and infusible drug formulations, announced today that Jessica Castle, M.D., an associate professor of medicine in the OHSU School of Medicine and OHSU Harold Schnitzer Diabetes Health Center in Portland, Oregon, is conducting a clinical trial with a dual-hormone artificial pancreas using Xeris’ ready-to-use liquid glucagon to evaluate a new closed-loop algorithm.Managing diabetes requires ongoing monitoring of blood glucose levels and regular intervention with glucose and insulin – a burdensome process for the over five million people on insulin in the United States. Automated insulin delivery (AID) systems available today can dial up and down or stop the delivery of insulin. They are limited in their ability to co-deliver glucagon, as current dry-powder glucagon formulations must be used immediately because they begin to degrade after reconstitution.Xeris’ ready-to-use liquid glucagon is room-temperature stable over extended periods of time, thereby enabling a dual-hormone artificial pancreas system to be possible. The ability to co-administer both insulin and stable liquid glucagon in one system may reduce the risk of hypoglycemia by mirroring the body’s normal glucose control, which is especially important during periods of exercise.Supported by funding from JDRF, the leading global organization funding type 1 diabetes (T1D) research, OHSU is conducting a Phase 1 single-center, randomized, three-way, controlled, crossover clinical study to test the efficacy of a new closed-loop algorithm for managing blood glucose in people with T1D before and after exercise.Related StoriesGut-boosting food may put an end to childhood malnutrition worldwideSmall bioengineered implant promises long-lasting relief from Type 1 diabetesNew implant technology safely minimizes injections for people with macular degeneration”JDRF is excited to support OHSU’s research into ready-to-use liquid glucagon,” said Marlon Pragnell, Ph.D., JDRF associate director of research. “This program has the potential to change the way millions of active individuals with T1D monitor and treat their glucose levels.”The purpose of this study is to determine whether a dual hormone artificial pancreas using Xeris’ ready-to-use liquid glucagon with an exercise detection algorithm outperforms both single hormone artificial pancreas and a low glucose suspend algorithm. In addition to the dual hormone therapy, this integrated system includes a continuous glucose monitor (“CGM”), an infusion pump, and a control algorithm that actuates the pump based upon real time CGM data. Study results are expected in the first half of 2019.”The goal in researching our liquid stable glucagon formulation as part of a dual-hormone closed-loop mated system is to overcome the limitations of current dry-powder glucagon formulations in automated pump systems to manage diabetes; this trial will help us better understand the potential application of our ready-to-use glucagon formulation,” said Paul R. Edick, Chairman and Chief Executive Officer of Xeris Pharmaceuticals. “Our research collaboration with OHSU and JDRF is an important opportunity to determine how a dual hormone artificial pancreas may help advance the standard of care for people with diabetes.”last_img read more

Breakthrough shows immune cells may play a role in schizophrenia

first_imgAustralian researchers have now found that among people with schizophrenia the number of these immune cells within the brain is raised. This is the first time that such a fact has been demonstrated say the experts. Professor Cyndi Shannon Weickert from Neuroscience Research Australia (NeuRA) said in a statement that this was an “unsolved mystery for a hundred years” and now it is solved. She said that this “new suspect” is detected to be present at the “scene of crime” when it was committed. She called the macrophages, “a new culprit that could be triggering schizophrenia.” The study results appear in the latest issue of the journal Molecular Psychiatry. By Dr. Ananya Mandal, MDSep 14 2018A type of immune cell called the “macrophages” are known to be one of the first soldiers of the body that can fight off infections and plays a role in maintaining immunity and in inflammation. According to latest research in schizophrenia, these macrophages can become altered and may cause changes in the brain leading to changes in the brain similar to schizophrenia.The term “macrophage” in Greek literally means “big eater”. These cells are capable of eating up or engulfing foreign bodies, infective cells, debris etc and generally maintain the housekeeping within the body. These cells function as first line soldiers when the body encounters an infection. Schizophrenia breakthrough. Image Credit: Neuroscience Research Australiacenter_img Related StoriesResearchers find new physical evidence in the brain for types of schizophreniaExploring how schizophrenia and depression are related to drug consumptionNew machine-learning method more precisely quantifies a known indicator for psychosisSchizophrenia is a psychotic brain disorder typically characterized by audio and visual hallucinations and delusions. According to the statistics nearly 100,000 Australians have psychosis. Na definite causes are known and no cure has been developed yet. Till date neurons or nerve cells, glial cells that support the neuron and endothelial cells that coat the inner walls of the blood vessels have been studied for possible mechanisms of psychosis and schizophrenia. The NeuRA researchers have now come up with the fourth compenent that could cause or trigger schizophrenia.The team found that in their subgroup of schizophrenics, 40 percent showed high levels of inflammation in their brains. Professor Weickert explained, “To find immune cells along the blood brain barrier in increased amounts in people with schizophrenia is an exciting discovery.” “It suggests immune cells themselves may be producing these inflammatory signals in the brains of people living with schizophrenia,” she said. She explained that the triggered glial cells could be signalling the endothelial cells of the blood vessels to alter their shapes and to call for the immune cells and capture them. These immune cells can now “transmigrate” past the blood brain barrier to enter the brain she said. The numbers are seen to be higher among those with schizophrenia compared to normal humans.At this stage of the research is not known if the immune cells are “harmful” or “helpful”. Professor Weickert said, what is clear is that schizophrenia researchers need to collaborate with immunologists to develop target therapies for schizophrenia. She said that may be if the immune cell movement to the brain were stopped, there could be improvement in the condition. More studies in future could help provide answers to the question say experts.Source: read more

Leading nutritionist explains about different types of iron in oral supplements

first_imgSep 19 2018Iron is the top nutritional deficiency in the world, as many as 80 percent of people do not have enough iron in their body according to the World Health Organization. What’s more, a 2016 study in medical journal The Lancet suggests that a third of the UK population have anemia, so their iron deficiency is at critically low levels.Typically, those with low iron levels are prescribed oral iron supplementation, but do people know what type of iron they are absorbing? Here, Leading Nutritionist Greg Weatherhead explains more about the different types of iron…“There are two categories of iron supplements, those which contain the ferrous form of iron and those which contain the ferric form” says Greg.“Ferric iron is the oxidized form of iron which makes it less reactive than the ferrous form, meaning it is less likely to act as a free radical and damage cells once within the body.Related StoriesBetterYou’s new Magnesium Bone Lotion helps maximize bone healthResearch finds link between increased vitamin K2 levels and reduced fracture rates in childrenVitamin D and magnesium supplements provide right nutritional support to athletes“One specific form of ferric iron, known as ferric EDTA, has been the subject of a large clinical trial demonstrating its superiority over other forms.“The trial, published in the Tanzanian Journal of Health Research, shows how a 5mg supplement of this form of iron provided the same increase in iron levels as a 10mg ferrous iron supplement.“This form of iron reduces the oxidative stress imposed on the body by the more reactive ferrous forms of this element which are known to cause more side effects.”Irrespective of the type of iron, any iron supplement which travels through the digestive system will have gastrointestinal side effects such as abdominal discomfort, nausea, vomiting and constipation.As iron is hard on the digestive tract only a fraction of the iron consumed will be absorbed, leaving the remaining iron to sit in the stomach, liver and large intestines, causing irritation.Aside from tablet forms, there are alternatives such as oral sprays which offer a solution to the digestive discomfort and poor absorption experienced from traditionally ingested iron supplements.An intra-oral spray does not rely on primary processing by the digestive system, with absorption beginning immediately in the mouthBetterYou’s award-winning Iron Oral Spray delivers 5mg of highly bioavailable, ferric EDTA iron. The tiny droplets within the spray absorb quickly into the inner cheek and rich vein network below, with absorption beginning immediately. It comes in a great tasting baked apple flavor to support usage.BetterYou’s Iron Oral Spray is available from and from all good health stores. BetterYou Iron Oral Spraycenter_img Source: read more

US declares war on Ebola epidemic

first_img Click to view the privacy policy. Required fields are indicated by an asterisk (*) Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Sign up for our daily newsletter Get more great content like this delivered right to you! Country The centerpiece of  what Obama called “a major increase in our response” indeed is the U.S. military, which in cooperation with the Liberian government will set up a command center in Monrovia led by U.S. Army Maj. Gen. Darryl Williams. As Obama explained, the military will set up a command and control, logistics and engineering to support civilian organizations working in the region. “Our Armed Services are better at that than any organization on Earth,” Obama said.The U.S. response will focus on providing beds for Ebola patients—which are almost nonexistent in Liberia—isolation spaces to hold people when Ebola Treatment Units have no space, more trained health care workers, an air bridge to move people and materiel into West Africa more quickly, and kits to help families with infected people in the house both care for an ailing person and protect themselves from infection. “We can’t dawdle on this one,” said Obama, who urged the global communities to dramatically step up their response, too. “International organizations just have to move faster than they have up until this point.” (This fact sheet explains the details of the revamped U.S. response.)At the 3-hour-long Senate hearing—which, in an unusual move, was jointly held by an appropriations subcommittee and the Committee on Health, Education, Labor and Pensions—topics ranged from financing the effort to the need for a greater sense of urgency, public health and scientific issues, and personal experiences. Beth Bell,  who directs CDC’s National Center for Emerging and Zoonotic Infectious Diseases, described the epidemic in Liberia, Sierra Leone, and Guinea as “ferocious and spreading exponentially,” so severely crippling the health care systems in some locales that malaria can’t be treated and infants cannot safely be delivered.Today’s situation report from the World Health Organization estimates that there have been nearly 5000 cases, nearly half of whom have died, but Bell says CDC believes “actual numbers would be two to three times higher.” She stressed that we have the tools to stop this epidemic but that the window of opportunity is closing. “If we do not act now to stop Ebola we could be dealing with it for years to come affecting larger areas of Africa,” she said.Senators repeatedly asked Anthony Fauci, head of the U.S. National Institute of Allergy and Infectious Diseases, whether the Ebola virus might mutate into a more dangerous form and even spread through the air. “We’re watching that carefully,” Fauci said. He explained that like all RNA viruses, the one that causes Ebola makes a lot of mistakes when it copies itself, but most of these mutations do nothing. “It is an unusual situation where a mutation will completely change the way that a virus is transmitted,” said Fauci, stressing that it was not impossible but highly unlikely. “What is likely is if we don’t do what we’re doing now, in the sense of a major ramping up of infection control capability, including what we’re hearing about getting the military heavily involved with all of the things they bring to the table … it’s going to get worse and worse,” Fauci said. “A virus that doesn’t replicate can’t mutate.”The U.S. Department of Defense is hoping to reprogram $500 million to Ebola efforts. The Obama administration has asked Congress to pass a continuing resolution that will give $30 million more dollars to CDC to use through 11 December, and $58 million to the Department of Health and Human Services to support development of experimental vaccines and treatments. The continuing resolution has passed the House of Representatives, and Senator Tom Harkin (D–IA), who chaired the joint committee hearing, said he expects the Senate to pass it “in the next day or two.” But Harkin and others stressed that more money will be need for the fiscal year 2015 budget. “I hate to say this but Ebola will not be conquered in the 10 weeks of the continuing resolution.”Harkin and other senators expressed surprise at the lack of a clear leader for the overall U.S. effort against Ebola. “I’m kind of startled to find that out,” Harkin said. Senator Barbara Mikulski (D–MD) said this was an issue the Senate needed to take up with Obama. “We need a point person,” Mikulski said. “If we wanted to meet with the person in charge, who would be the person in charge?”The hearing ended with testimony and questions of Brantly, an American doctor with Samaritan’s Purse who was airlifted from Monrovia to Atlanta for state-of-the-art care and is doing well today. Brantly, who met with Obama in the Oval Office this morning, spoke of the many people he treated who died of Ebola and the urgent need for healthcare workers from other countries to go help in West Africa.“Many, including one of the senators today, used the analogy of a fire burning out of control to describe this unprecedented Ebola outbreak,” Brantly said. “Indeed it is a fire. It is a fire straight from the pit of hell. We cannot fool ourselves into thinking that the vast moat of the Atlantic Ocean will protect us from the flames of this fire. Instead we must move quickly and immediately to deliver the promises that have been made and to be open to practical, innovative interventions. This is the only way to keep entire nations from being reduced to ashes.”*The Ebola Files: Given the current Ebola outbreak, unprecedented in terms of number of people killed and rapid geographic spread, Science and Science Translational Medicine have made a collection of research and news articles on the viral disease freely available to researchers and the general public.center_img Mark 16 September 2014 as the day the United States declared an all-out war on the Ebola epidemic raging in West Africa.As President Barack Obama explained in remarks he made today at the U.S. Centers for Disease Control and Prevention (CDC) in Atlanta, the world is looking to the United States for help. “It’s a responsibility we embrace,” Obama said. “We’re prepared to take leadership on this to provide the kinds of capabilities that only America has, and to mobilize the world in ways that only America can do.  That’s what we’re doing as we speak.”At the same time Obama was speaking in Atlanta, the U.S. Senate held an Ebola hearing that featured testimony from leading public health officials and perhaps the world’s most famous Ebola survivor, Kent Brantly, who became ill with the disease while treating patients in Liberia in July. “We must take the deadly dangerous threat of the Ebola epidemic as seriously as we take ISIS [Islamic State in Iraq and Syria],” said Senator Lamar Alexander (R–TN). Emaillast_img read more

Europe moves ahead with Mars mission kills asteroid lander

first_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country “Today I am very confident we will do it. We have some contingency,” ESA Director General Jan Wörner told a postcouncil press conference today.ESA’s central funding won a modest increase of 1% per year before inflation. Wörner pointed out that, with inflation as low as it is today, that does represent some growth in funding, but it doesn’t mean life will be easy. “We are in a little bit of a difficult situation: That increase will be eaten up by ExoMars. We didn’t get a free ticket from the member states,” he said. If inflation increases, then the trouble will mount, because it will eat into the budget for science missions which, with €508 million in 2017, form the biggest budget line in ESA’s central funding.Despite the strained circumstances, ESA Director of Science Alvaro Giménez Cañete told reporters that: “We can do what we’re committed to and can launch what we’re planning to launch up to 2021.” ESA science missions due for launch in that time span include the Cheops mission to study exoplanet transits, the BepiColombo probe to Mercury, the Solar Orbiter, and the Euclid dark energy mission.ESA member states also reasserted their commitment to the International Space Station (ISS) by approving nearly €1 billion in funding to remain part of the project beyond the current 2020 agreement to 2024. As part of the current deal, ESA is building a service module for NASA’s Orion capsule. The module will provide electricity, water, oxygen, and nitrogen for astronauts, as well as propulsion once Orion is in orbit. By agreeing to extend ISS operations, ESA commits itself to building a second-service module as part of a barter arrangement with NASA.Asteroid researchers will be dismayed to hear of the demise of AIM. The mission intended to send a small spacecraft to a 170-meter lump of rock nicknamed Didymoon, because it orbits around a slightly larger asteroid called Didymos. Didymoon is interesting because a NASA mission called Double Asteroid Redirection Test is intending to smash into it at 6 kilometers per second to see what effect that has on its motion. AIM would have observed the condition of the asteroid before and after the collision. Wörner said he will be traveling to Washington, D.C., next week to discuss with NASA what the AIM cancellation means for the joint mission.Looking further ahead, Wörner said the agency was looking into the possibility of building a “moon village.” This would not be a solely European effort but a multiparty collaboration with contributions from space agencies and industry. The concept doesn’t have a budget line but it has “started already,” says Wörner, adding: “ESA needs visionary programs for the future.” Click to view the privacy policy. Required fields are indicated by an asterisk (*) Europe’s ExoMars 2020 lander will go ahead as scheduled, despite the failure of the test-run Schiaparelli lander this past October, the European Space Agency (ESA) said today at the end of a council meeting at which government ministers from its 22 member states agreed on budgets for the next several years. ESA won a total of €10.3 billion for a wide range of projects extending into next decade but because the agency had requested €11 billion, some belt tightening will be required. And there was one notable casualty: the Asteroid Impact Mission (AIM), which planned to study in detail and land on a near-Earth asteroid in 2022, did not win enough support from member governments to proceed.There will be huge relief that ministers supported going ahead with ExoMars 2020 as planned, because it has been on the books at ESA for more than a decade. The mission carries a rover that will be able to, for the first time, drill as deep as 2 meters below the surface in search of present or past life. The first part of the ExoMars program—the Trace Gas Orbiter (TGO)—successfully entered Mars orbit in October. It carried with it Schiaparelli, a demonstrator designed to test landing technology. But after a faultless atmospheric entry, a software error caused Schiaparelli to think it was on the surface when it was still kilometers from landing and it subsequently crashed.Because Schiaparelli was able to transmit data during the landing to the TGO, ESA engineers believe they can avoid a similar mishap in 2020. But it remained to be seen whether ESA members agreed with them. They did; today, ministers approved the €440 million funding needed to complete the ExoMars mission, but with caveats. Some €97 million of the total must come not from the ExoMars budget line, but from ESA’s central funding, which pays for other science missions. That could potentially lead to conflicts down the line.center_img Email Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwelast_img read more

Jack Nicholsons Psychedelic Film about an Acid Trip was Banned in Britain

first_imgIn the 1960s the United States was hit with a growing counter-culture which challenged the traditional values of its society. Apart from large popular movements which shaped the political landscape, new art forms were breaking barriers as well ― especially in music and cinema. At the time, combining the two proved to be the next big thing. As psychedelic rock emerged, spawning the hippie subculture, low-budget films thrived on their independence from big studios, practicing new and subversive methods which made them the avant-garde of the art world.Young people near the Woodstock festival in August 1969. Photo by Ric Manning CC BY 3.0However, their efforts often encountered disagreement and censorship by the establishment for depictions of nudity, drug use or explicit violence, which were just some of the traits found in indie films of the time.Another trademark was the strong anti-war subtext, regarding the U.S. military interventions in Vietnam and other parts of the world.Vietnam War protesters 1967.On the forefront of this cinematic movement were some household names of the movie business today, like Peter Fonda, Dennis Hopper, and Jack Nicholson. In fact, all three of them took part in the 1969 cult classic Easy Rider which defined the hippie era.Peter Fonda riding Captain America. Photo by Brian Snelson CC BY 2.0But before Easy Rider, in 1967 the trio was involved in another production ― one that saw very limited release and was even banned in the U.K. for more than three decades. The film, simply called The Trip, was produced by MGM, written by Jack Nicholson and directed by Roger Corman, a prolific film director whose experimental approach pioneered alternative cinema in the U.S.Captain America, Harley Davidson Chopper featured in Easy Rider. Photo by Joachim Köhler CC BY-SA 3.0Corman and Nicholson worked together on several prior productions such as The Little Shop of Horrors, The Raven and The Terror. Jack Nicholson also starred in another psychedelic movie themed around drug use in 1968’s Psych Out.The Trip’s plot revolves around a TV director, portrayed by Peter Fonda, who decides to consume LSD after a tough divorce from his wife. In the search for meaning, he gets entangled in a bad trip, encounters various characters along the way and is constantly chased by a group of dark, hooded horsemen.These apocalyptic visions melt with psychedelic imagery and erotic scenes, as the main character transgresses from his old self into someone different.Exterior scenes taking place in the Sunset Strip were edited by Corman himself, who even took LSD in order to better understand the main character’s experience. Corman’s chaotic editing of abstract imagery came as a direct result of trying to transfer the influence of LSD onto the screen, simulating its effects on the human mind and perception.Earl Carroll Theatre, Sunset Strip, Los Angeles, California.While providing the viewer an insight into the LSD-induced paranoia, the director at one point subtly addresses the U.S.-backed invasion of Cuba in 1966, commonly referred to as the Bay of Pigs.Most of the music in the film is performed by Mike Bloomfield and his band The Electric Flag, providing jazz-influenced improvisations together with a blues-rock background, adding to the disoriented feeling of the movie.Every Day Items Used As Movie PropsAlthough Fonda rooted for another musical outfit to provide the music score, called The International Submarine Band, in the final cut they only appear as a band performing in a nightclub, with The Electric Flag score in the background.As for the screenplay, it was written by Nicholson, who was a relatively unknown figure at the time. He was hired by Corman after several drafts written by other authors failed to meet his expectations.Nicholson as Wilbur Force in The Little Shop of Horrors (1960).Reportedly, Corman liked Nicholson’s experimental approach to writing, claiming in the commentary section of the 2004 DVD release that between 80 and 90 percent of the script entered the final cut, with only minor changes made by the director himself, in order to meet the budget requirements.The visual style of the picture, along with its direct depiction of LSD abuse caused The Trip to have a limited release only in selected theaters, but the movie managed to earn around 6 million dollars from a budget of 100 thousand, becoming an instant classic.Movie poster for The Trip. Wikipedia @1967 American International PicturesSince it was released in 1967, at the very climax of the so-called “Summer of Love,” it made a significant cultural impact garnering a cult following and widespread praise.However, across the ocean in Britain, it met with a censorship committee which deemed it unsuitable for theatrical release in 1967.In 1971 The Trip was once again sent overseas by MGM, only to be rejected for the second time. The same thing happened in 1980. In 1988, it once again failed to gain a certificate, this time for video release.Finally, after more than three decades of it being blacklisted, Britain got the chance to watch the The Trip in 2004, when it was released on DVD, with the commentary included.LSD tabs with hearts on themAfter 37 years, the audience in Britain was finally allowed to watch what was dubbed by critics as the best depiction of an LSD trip ever put on film. Of course, in the meantime it has become more of a relic of the turbulent sixties than a potential subversive artistic endeavor that threatens to incite the British youth to consume LSD.Read another story from us: Jack Nicholson’s Sister was Actually his MotherToday, the film is widely available and distributed all around the world, as it remains a sort of “Midnight Movie” favorite among film buffs and art-house filmmakers who perceive it as a milestone achievement of the era.Nikola Budanovic is a freelance journalist who has worked for various media outlets such as Vice, War History Online, The Vintage News, and Taste of Cinema. His main areas of interest are history, particularly military history, literature and film.last_img read more

Two American women six children repatriated to US from SyriaKurdishled authority

first_imgBut few countries want to take back their citizens, who may be hard to prosecute, and the prospect has sparked fierce debate in their home countries where there is little public sympathy for the families of jihadists.Abdulkarim Omar, the co-chair of foreign relations in the Kurdish-led region, said foreign governments now appeared more willing to repatriate citizens but “only humanitarian causes”. He told Reuters he expected more foreign women and children to be sent home from Syria in the near future.Omar said the eight Americans were due to arrive in the United States on Wednesday.The Kurdish-led administration, which controls swathes of north and east Syria, said it had helped repatriate them based on their “free and voluntary desire to return to their country.” Islamic State expands reach in Afghanistan, threatening West The Islamic state, Beirut, Syria, Abdulkarim Omar, America, jihadi, foreign prisoners, world, Indian Express The Kurdish-led forces are holding the women and children in already overflowing camps, on top of hundreds of foreign fighters in prisons. (File Photo)Two US women with Islamic State ties and six children were repatriated from northeast Syria, Kurdish-led authorities, saying their return came at the request of the US government. Advertising Related News By Reuters |Beirut | Published: June 5, 2019 4:59:07 pm NIA seeks permission to question three men to ‘unravel larger IS plot’ Advertising Islamic State man from Kerala tells family he wants to return The eight Americans are among thousands of wives and children of foreign jihadists detained by US-backed forces who defeated the last Islamic State foothold in eastern Syria in March.The Kurdish-led forces are holding the women and children in already overflowing camps, on top of hundreds of foreign fighters in prisons.Kurdish leaders say they cannot hold the foreigners forever and warn that the prisoners pose a threat in northeast Syria. 0 Comment(s)last_img read more

Two dead after light planes collide midair in New Zealand

first_imgBy Reuters |Melbourne | Published: June 16, 2019 1:15:06 pm Advertising Advertising Two dead after light planes collide mid-air in New Zealand There was no immediate information about a potential cause of the crash and the police would not release the names of the victims, saying they were still trying to locate family members. (Representational)Two light aircraft collided mid-air on their final approach at a regional aerodrome in New Zealand on Sunday killing both pilots, police said. LiveKarnataka floor test: Will Kumaraswamy’s 14-month-old govt survive? Virat Kohli won’t have a say in choosing new coach After Masood Azhar blacklisting, more isolation for Pakistan Top News Four parachutists on board of one of the planes had jumped shortly before it crashed with the other plane, a training aircraft. A helicopter, also preparing to land, managed to avoid the collision.The police said that both planes dropped immediately after impact, hitting the ground south of the Hood Aerodrome near the town of Masterton.There was no immediate information about a potential cause of the crash and the police would not release the names of the victims, saying they were still trying to locate family members. Witnesses told New Zealand media that they heard a loud bang and saw the planes spiraling, a New Zealand news website, cited a local pilot instructor saying the aerodrome was unrestricted up to 9,500 feet, but pilots were required to record their movements through a shared radio channel.One of the planes belonged to Skydive Wellington while the other to the Wairarapa Aero Club. The Hood Aerodrome is owned and operated by the Masterton District Council.“We have a close-knit community at Hood Aerodrome and the incident has understandably rocked that community,” the council said in a statement on its website. Post Comment(s)last_img read more

Four injured after gunman opens fire in San Franciscoarea shopping mall

first_img Advertising Related News Man behind San Francisco’s facial recognition ban is working on more — way more By Reuters |San Francisco | Published: July 3, 2019 7:17:51 am San Francisco, San Francisco shooting, San Francisco mall shooting, US San Francisco, US gun laws, world news The shopping mall in San Bruno, located south of San Francisco, was closed after the gunfire, police said on Twitter.Two people were shot and two others hurt on Tuesday when at least one gunman opened fire at a mall in the San Francisco suburb of San Bruno before apparently fleeing on a nearby train, police said. San Francisco becomes first US city to ban e-cigarette sales Explained: The push for, and the pushback against, facial recognition technology Advertising Post Comment(s) Barberini said police were searching for one or possibly two gunmen who may have fled the scene by getting on a BART train headed for Oakland.The shopping mall in San Bruno, located south of San Francisco, was closed after the gunfire, police said on Twitter.The Bay Area Rapid Transit authority said one of its commuter stops was shut down as a precaution after the shooting Two people were taken to San Francisco General Hospital with gunshot wounds to their lower bodies in stable condition, San Bruno Police Chief Ed Barberini told reporters at a late-afternoon news conference.“It was a senseless act,” Barberini said, adding that opening fire in a crowded shopping mall near a Bay Area Rapid Transit (BART) station showed a “true disregard for human life.”Two other people were treated at the scene for minor injuries they suffered in fleeing from the gunmen.last_img read more

Next Dalai Lama must be chosen within China India should not intervene

first_img Karnataka trust vote today: Speaker’s call on resignations, says SC, but gives rebel MLAs a shield Advertising dalai lama, dalai lama successor, successor of dalai lama, china will choose dalai lama, next dalai lama, who is nest dalai lama, indian express The Dalai Lama is 84 years old now and the issue of his successor has gained prominence in the last couple of years in the wake of his health issues. (File Photo)The successor of the Dalai Lama has to be decided within China and any interference by India on the issue will impact bilateral ties, Chinese authorities have said. Dalai Lama says sorry for his ‘successor should be attractive’ remark “The Dalai Lama’s reincarnation is not decided by his personal wish or by some group of people living in other countries,” he added.Wang, the director-general at the government of Tibet Autonomous Region, said the current Dalai Lama was recognised by Beijing and his successor must be found through the “draw of lots in golden urn process” within China.Echoing Wang’s views, Zha Luo, director at Beijing-based China Tibetology Research Centre, a government-run influential think tank, said any refusal by India to recognise the next Dalai Lama to be chosen within China will impact bilateral ties.The 14th Dalai Lama fled to India in 1959 following a crackdown on an uprising by the local population in Tibet. Dalai Lama’s remark that a female successor ‘should be more attractive’ irks many Taking stock of monsoon rain Nepal govt says no to Dalai Lama birthday More Explained India granted him political asylum and the Tibetan government-in-exile is based on Dharamsala in Himachal Pradesh since then.“It will be a major political difference that would impact bilateral relations and any wise political leader wouldn’t do that,” said Zha whose team advises central government on policy issues for Tibet.He was asked what will happen if India refuses to recognise the next Dalai Lama chosen by China.“Since the reincarnation of the Dalai Lama is an important issue for China any friendly country or friend of China would not interfere or meddle on the issue,” he added. Advertising Best Of Express Zha, however, called it a hypothetical answer to a hypothetical question.India has maintained its stand on the Dalai Lama.“Government of India’s position on His Holiness the Dalai Lama is clear and consistent. He is a revered religious leader and is deeply respected by the people of India. There is no change in that position. His Holiness is accorded all freedom to carry out his religious activities in India,” Ministry of External Affairs spokesperson had told a media briefing in March last year.Wang said the process of selecting the next Dalai Lama must follow two clear steps : “It must go to draw of lots in the golden urn and the reincarnation must be recognised by the central government”.He said the “centrality” of the central government must be recognised and that any personal move by the current Dalai Lama on the issue is not going to be recognised by Chinese government or religious followers in Tibet.“It was with the central government’s recognition that the Dalai Lama became 14th Dalai Lama. Otherwise, he wouldn’t have been in that position,” said Wang.He alleged that the Dalai Lama has been “inciting” and “misguiding” young Tibetan people for his political motives.Asked about the Dalai Lama’s comments that he was ready to accept Tibet as part of China, Wang said he has been resorting to political rhetoric without taking any action.“He still believes that Tibet is an independent country. Without any concrete moves from his side, his words do not mean anything,” Wang added.Asked about assertion by Chinese authorities on the Dalai Lama’s successor, an official in the Tibetan government-in excile called it a “ploy to politicise the issue of reincarnation.”“It will help them strengthen their rule and obliterate Tibetan identity, culture, language and way of life,” he said.Wang said there were around 10 rounds of discussions between private representatives of Dalai Lama and Beijing. The last round took place in 2011 in Beijing.“The discussions were about the future of the Dalai Lama and did not include or touch on the topic of future of Tibet as a part of China’s sovereign territory,” Wang said.The Indian government had issued a note nearly a year back to senior officials, asking them not to attend events organised by the Tibetan government-in-exile. Cabinet asks finance panel to consider securing funds for defence Advertising Related News After Masood Azhar blacklisting, more isolation for Pakistan In first clear assertion on the sensitive issue, senior Chinese officials and experts said the reincarnation of the Dalai Lama must be approved by the Chinese government and the selection should take place within the country based on an over 200-year-old historical process.“The reincarnation of Dalai Lama is a historical, religious and political issue. There are established historical institutions and formalities for the reincarnation of the Dalai Lama,” Wang Neng Sheng, an official in the rank of vice minister in Tibet, told a small group of Indian journalists in Lhasa.The Dalai Lama is 84 years old now and the issue of his successor has gained prominence in the last couple of years in the wake of his health issues. By PTI |Beijing, Lhasa | Published: July 14, 2019 10:25:18 pm India has also been supporting the ‘One China’ policy, which states that Taiwan and Tibet are part of China’s mainland. Beijing made the ‘One-China’ policy a prerequisite for countries to establish diplomatic ties with it. Post Comment(s)last_img read more